Correlated substitution analysis and the prediction of amino acid structural contacts
نویسندگان
چکیده
منابع مشابه
Correlated substitution analysis and the prediction of amino acid structural contacts
It has long been suspected that analysis of correlated amino acid substitutions should uncover pairs or clusters of sites that are spatially proximal in mature protein structures. Accordingly, methods based on different mathematical principles such as information theory, correlation coefficients and maximum likelihood have been developed to identify co-evolving amino acids from multiple sequenc...
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ژورنال
عنوان ژورنال: Briefings in Bioinformatics
سال: 2007
ISSN: 1467-5463,1477-4054
DOI: 10.1093/bib/bbm052